EdenteV2, Main, Exploration, bibRecord, 009D06

Complications following definitive irradiation for cancers of the oral cavity and the oropharynx (in a series of 1134 patients)

Identifieur interne : 009D06 ( Main/Exploration ); précédent : 009D05; suivant : 009D07

Complications following definitive irradiation for cancers of the oral cavity and the oropharynx (in a series of 1134 patients)

Auteurs : Monique Pernot [France] ; Elisabeth Luporsi [France] ; Sylvette Hoffstetter [France] ; Didier Peiffert [France] ; Pierre Aletti [France] ; Christian Marchal [France] ; Przemislaw Kozminski [France] ; Alain Noël [France] ; Pierre Bey [France]

Source :

International Journal of Radiation Oncology, Biology, Physics [ 0360-3016 ] ; 1997.

RBID : ISTEX:318704B266DACAAA2611836271E82F971B39B6B6

English descriptors

Abstract

Abstract: Purpose: To study the rate and severity of complications in a series of 1134 patients treated by definitive irradiation for tumors of the oral cavity (772 cases) or the oropharynx (361 cases). Methods and Materials: Patients were staged as 29.5% T1, 42% T2, 26% T3, 2.5% T4-Tx, and 74.5% N0 tumors. We treated 364 patients with brachytherapy only (192Ir) for the primary lesion. External irradiation and brachytherapy were combined for 770 patients. Results: The results included local control and survival. Out of 1134 patients, 330 had 376 complications. Grace 1 complications occurred in 20% of the patients, Grade 2 in 9%; Grade 3 in 4%; and Grade 4 in 0.2%. Of the Grade 1 complications, 78% were soft tissue and only 24% were bone complications. For the more severe grades (2,3, and 4), there were 56 soft tissue complications and 90 bone complications out of 1340 patients. The statistical analysis included tumor-related factors and treatment-related factors. For the first two factors, only tumor location was significant. The treatment-related factors significant for complications were studied in univariate and multivariate study. This multivariate study confirmed that for soft tissue complications dose rate and volume treated were important (p < 0.001). It also complications, total dose >80 Gy, dose rate >0.7 Gy/h, and the absence of leaded protection of the mandible were all important factors. Conclusion: This statistical study should allow future reduction of severe complications (Grades 2, 3, 4), if treatment factors inducing them can be taken into account. This is not always possible for very large tumors.

Url:

https://api.istex.fr/document/318704B266DACAAA2611836271E82F971B39B6B6/fulltext/pdf

DOI: 10.1016/S0360-3016(96)00612-8

Affiliations:

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Le document en format XML

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<author><name sortKey="Kozminski, Przemislaw" sort="Kozminski, Przemislaw" uniqKey="Kozminski P" first="Przemislaw" last="Kozminski">Przemislaw Kozminski</name>
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<term>Biol</term>
<term>Bone complications</term>
<term>Brachy</term>
<term>Brachytherapy</term>
<term>Carcinoma</term>
<term>Cavite buccale</term>
<term>Centre alexis vautrin</term>
<term>Clinical experience</term>
<term>Complication</term>
<term>Definitive irradiation</term>
<term>Dental care</term>
<term>Dental extractions</term>
<term>Dos</term>
<term>Dose rate</term>
<term>Dose rates</term>
<term>Doserate surfacetreated</term>
<term>External beam</term>
<term>External beam irradiation</term>
<term>External irradiation</term>
<term>External radiotherapy</term>
<term>Important factor</term>
<term>Important factors</term>
<term>Intercurrent disease</term>
<term>Interstitial</term>
<term>Interstitial brachytherapy</term>
<term>Interstitial implantation</term>
<term>Large tumors</term>
<term>Last group</term>
<term>Late effects</term>
<term>Leaded</term>
<term>Leaded protection</term>
<term>Lesion</term>
<term>Local control</term>
<term>Mandible</term>
<term>Many authors</term>
<term>Median</term>
<term>Median time</term>
<term>Mobile tongue</term>
<term>Moderate grade</term>
<term>More bone complications</term>
<term>More complications</term>
<term>Multivariate</term>
<term>Multivariate study</term>
<term>Neck dissection</term>
<term>Neck localizations</term>
<term>Neck radiotherapy</term>
<term>Necrosis</term>
<term>Nodal areas</term>
<term>Nodal involvement</term>
<term>Oncol</term>
<term>Oral cavity</term>
<term>Oropharynx</term>
<term>Oropharynx primaries</term>
<term>Other patients</term>
<term>Paris system</term>
<term>Patient factors</term>
<term>Phys</term>
<term>Pillar pharyngoglossal sulcus</term>
<term>Positive nodes</term>
<term>Primary lesion</term>
<term>Primary tumor</term>
<term>Radiat</term>
<term>Radiation necrosis</term>
<term>Radiation oncology</term>
<term>Radiation therapy</term>
<term>Radioactive lines</term>
<term>Radiother</term>
<term>Radiotherapy</term>
<term>Retrospective study</term>
<term>Safety margin</term>
<term>Second cancer</term>
<term>Severe complications</term>
<term>Severe grade</term>
<term>Shorter duration</term>
<term>Significant difference</term>
<term>Significant increase</term>
<term>Soft palate</term>
<term>Soft tissue</term>
<term>Soft tissue complications</term>
<term>Soft tissuecomplications</term>
<term>Soft tissues</term>
<term>Spinal cord</term>
<term>Squamous cell carcinoma</term>
<term>Surface area</term>
<term>Third complications</term>
<term>Tissue complications</term>
<term>Tobacco abuse</term>
<term>Total dose</term>
<term>Treatment factors</term>
<term>Univariate study</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Anterior field</term>
<term>Biol</term>
<term>Bone complications</term>
<term>Brachy</term>
<term>Brachytherapy</term>
<term>Carcinoma</term>
<term>Cavite buccale</term>
<term>Centre alexis vautrin</term>
<term>Clinical experience</term>
<term>Complication</term>
<term>Definitive irradiation</term>
<term>Dental care</term>
<term>Dental extractions</term>
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<term>Dose rate</term>
<term>Dose rates</term>
<term>Doserate surfacetreated</term>
<term>External beam</term>
<term>External beam irradiation</term>
<term>External irradiation</term>
<term>External radiotherapy</term>
<term>Important factor</term>
<term>Important factors</term>
<term>Intercurrent disease</term>
<term>Interstitial</term>
<term>Interstitial brachytherapy</term>
<term>Interstitial implantation</term>
<term>Large tumors</term>
<term>Last group</term>
<term>Late effects</term>
<term>Leaded</term>
<term>Leaded protection</term>
<term>Lesion</term>
<term>Local control</term>
<term>Mandible</term>
<term>Many authors</term>
<term>Median</term>
<term>Median time</term>
<term>Mobile tongue</term>
<term>Moderate grade</term>
<term>More bone complications</term>
<term>More complications</term>
<term>Multivariate</term>
<term>Multivariate study</term>
<term>Neck dissection</term>
<term>Neck localizations</term>
<term>Neck radiotherapy</term>
<term>Necrosis</term>
<term>Nodal areas</term>
<term>Nodal involvement</term>
<term>Oncol</term>
<term>Oral cavity</term>
<term>Oropharynx</term>
<term>Oropharynx primaries</term>
<term>Other patients</term>
<term>Paris system</term>
<term>Patient factors</term>
<term>Phys</term>
<term>Pillar pharyngoglossal sulcus</term>
<term>Positive nodes</term>
<term>Primary lesion</term>
<term>Primary tumor</term>
<term>Radiat</term>
<term>Radiation necrosis</term>
<term>Radiation oncology</term>
<term>Radiation therapy</term>
<term>Radioactive lines</term>
<term>Radiother</term>
<term>Radiotherapy</term>
<term>Retrospective study</term>
<term>Safety margin</term>
<term>Second cancer</term>
<term>Severe complications</term>
<term>Severe grade</term>
<term>Shorter duration</term>
<term>Significant difference</term>
<term>Significant increase</term>
<term>Soft palate</term>
<term>Soft tissue</term>
<term>Soft tissue complications</term>
<term>Soft tissuecomplications</term>
<term>Soft tissues</term>
<term>Spinal cord</term>
<term>Squamous cell carcinoma</term>
<term>Surface area</term>
<term>Third complications</term>
<term>Tissue complications</term>
<term>Tobacco abuse</term>
<term>Total dose</term>
<term>Treatment factors</term>
<term>Univariate study</term>
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<front><div type="abstract" xml:lang="en">Abstract: Purpose: To study the rate and severity of complications in a series of 1134 patients treated by definitive irradiation for tumors of the oral cavity (772 cases) or the oropharynx (361 cases). Methods and Materials: Patients were staged as 29.5% T1, 42% T2, 26% T3, 2.5% T4-Tx, and 74.5% N0 tumors. We treated 364 patients with brachytherapy only (192Ir) for the primary lesion. External irradiation and brachytherapy were combined for 770 patients. Results: The results included local control and survival. Out of 1134 patients, 330 had 376 complications. Grace 1 complications occurred in 20% of the patients, Grade 2 in 9%; Grade 3 in 4%; and Grade 4 in 0.2%. Of the Grade 1 complications, 78% were soft tissue and only 24% were bone complications. For the more severe grades (2,3, and 4), there were 56 soft tissue complications and 90 bone complications out of 1340 patients. The statistical analysis included tumor-related factors and treatment-related factors. For the first two factors, only tumor location was significant. The treatment-related factors significant for complications were studied in univariate and multivariate study. This multivariate study confirmed that for soft tissue complications dose rate and volume treated were important (p < 0.001). It also complications, total dose >80 Gy, dose rate >0.7 Gy/h, and the absence of leaded protection of the mandible were all important factors. Conclusion: This statistical study should allow future reduction of severe complications (Grades 2, 3, 4), if treatment factors inducing them can be taken into account. This is not always possible for very large tumors.</div>
</front>
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<name sortKey="Aletti, Pierre" sort="Aletti, Pierre" uniqKey="Aletti P" first="Pierre" last="Aletti">Pierre Aletti</name>
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Complications following definitive irradiation for cancers of the oral cavity and the oropharynx (in a series of 1134 patients)

Complications following definitive irradiation for cancers of the oral cavity and the oropharynx (in a series of 1134 patients)

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Abstract

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